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ROS as a tumour suppressor?

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Senescence is an important mechanism for suppressing mammalian tumours and it may also contribute to aging. A new study suggests that changes in the metabolism of oxygen radicals are important for establishing senescence and blocking cytokinesis to ensure senescent cells never divide again.

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Figure 1: Senescence requires a mitogenic signal under conditions of cellular stress.

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Acknowledgements

We would like to thank W. Kim for comments of the manuscript.

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Authors and Affiliations

  1. Departments of Medicine and Genetics, The Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, 27599-7295, NC, USA

    Matthew R. Ramsey & Norman E. Sharpless

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  1. Matthew R. Ramsey
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  2. Norman E. Sharpless
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Ramsey, M., Sharpless, N. ROS as a tumour suppressor?. Nat Cell Biol 8, 1213–1215 (2006). https://doi.org/10.1038/ncb1106-1213

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