Skip to main content
SpringerLink
Log in

A-kinase anchoring proteins: different partners, different dance

  • News & Views
  • Published:

From Nature Cell Biology

View current issue Submit your manuscript

How do cells achieve specific and efficient control over a wide spectrum of activities in the context of a limited protein repertoire? A possible answer comes from the recent demonstration that utilization of distinct enzymes by the same A-kinase anchoring protein (AKAP) depends on the AKAP-bound substrate, thus vastly increasing the diversity of AKAP-mediated protein regulation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: The same AKAP mediates regulation of two distinct types of ion channel using different enzymes

References

  1. Michel, J.J. & Scott, J.D. Annu. Rev. Pharmacol. Toxicol. 42, 235–257 (2002).

    Article  CAS  Google Scholar 

  2. Herberg, F.W., Maleszka, A., Eide, T., Vossebein, L. & Tasken, K. J. Mol. Biol. 298, 329–339 (2000).

    Article  CAS  Google Scholar 

  3. Bauman, A.L., Goehring, A.S. & Scott, J.D. Neuropharmacology 46, 299–310 (2004).

    Article  CAS  Google Scholar 

  4. Hoshi, N, Langeberg, L., Scott, J.D. Nature Cell Biol. 7, 1066–1073 (2005).

    Article  CAS  Google Scholar 

  5. Banke, T.G. et al. J. Neurosci. 20, 89–102 (2000).

    Article  CAS  Google Scholar 

  6. Tavalin, S.J. et al. J. Neurosci. 22, 3044–3051 (2002).

    Article  CAS  Google Scholar 

  7. Hoshi, N. et al. Nature Neurosci. 6, 564–571 (2003).

    Article  CAS  Google Scholar 

  8. Bosma, M.M. & Hille, Proc. Natl Acad. Sci. U S A 86, 2943–2947 (1989).

    Article  CAS  Google Scholar 

  9. Wong, W. & Scott, J.D. Nature Rev. Mol. Cell Biol. 5, 959–970 (2004).

    Article  CAS  Google Scholar 

  10. Carnegie, G.K., Smith, F.D., McConnachie, G., Langeberg, L.K. & Scott, J.D. Mol. Cell 15, 889–899 (2004).

    Article  CAS  Google Scholar 

  11. Kurokawa, J., Motoike, H.K., Rao, J . & Kass, R.S. Proc. Natl Acad. Sci. U S A 101, 16374–16378 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, Columbia University Medical Center, 630 W. 168th St., New York, 10032, NY, USA

    Lei Chen & Robert S. Kass

Authors
  1. Lei Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Robert S. Kass
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chen, L., Kass, R. A-kinase anchoring proteins: different partners, different dance. Nat Cell Biol 7, 1050–1051 (2005). https://doi.org/10.1038/ncb1105-1050

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb1105-1050

  • Springer Nature Limited

This article is cited by

Search

Navigation