Skip to main content

Advertisement

SpringerLink
Log in

Wnt signalling sees spots

  • News & Views
  • Published:

From Nature Cell Biology

View current issue Submit your manuscript

The organization of signalling complexes represents the coalescence of cell biology and signal transduction. Recent work on Dishevelled (Dvl), a multifunctional component of the Wnt–Frizzled (Fz) signalling pathway, ascribes vesicle- and actin-binding properties to a single domain within the protein. This could represent a critical point for divergence of the Wnt signalling pathway.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Dvl has distinct functions.

References

  1. Wallingford, J. B., Fraser, S. E. & Harland, R. M. Dev. Cell 6, 695–706 (2002).

    Article  Google Scholar 

  2. Axelrod, J. D., Miller, J. R., Shulman, J. M., Moon, R. T. & Perrimon, N. Genes Dev. 16, 2610–2622 (1998).

    Article  Google Scholar 

  3. Penton, A., Wodarz, A. & Nusse, R. Genetics 161, 747–762 (2002).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Wallingford, J. B. et al. Nature 405, 81–85 (2000).

    Article  CAS  PubMed  Google Scholar 

  5. Habas, R., Kato, Y. & He, X. Cell 107, 843–854 (2001).

    Article  CAS  PubMed  Google Scholar 

  6. Tree, D. R., et al. Cell 109, 371–381 (2002).

    Article  CAS  PubMed  Google Scholar 

  7. Wong, H. C. et al. Nature Struct. Biol. 12, 1178–84 (2000).

    Google Scholar 

  8. Khlebtsova, N., Hung, L. W., Henderson, K., Moon, R. & Earnest, T. Acta Crystallogr. D. Biol. Crystallogr. 56, 212–214 (2000).

    Article  CAS  PubMed  Google Scholar 

  9. Axelrod, J. D. Genes Dev. 15, 1182–1187 (2001).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Capelluto, D. G. S. et al. Nature 419, 726–729 (2002).

    Article  CAS  PubMed  Google Scholar 

  11. Yanagawa, S., van Leeuwen, F., Wodarz,A., Klingensmith, J. & Nusse, R. Genes Dev. 9, 1087–1097 (1995).

    Article  CAS  PubMed  Google Scholar 

  12. Torres, M. A. & Nelson, W. J. J. Cell Biol. 149, 1433–1442 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Sun, T. Q. et al. Nature Cell Biol. 3, 628–636 (2001).

    Article  CAS  PubMed  Google Scholar 

  14. Peters, J. M., McKay, R. M., McKay, J. P. & Graff, J. M. Nature 401, 345–350 (1999).

    Article  CAS  PubMed  Google Scholar 

  15. Sakanaka, C., Leong, P., Xu, L., Harrison, S. D. & Williams, L. T. Proc. Natl Acad. Sci. USA 96, 12548–12552 (1999).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Developmental Biology and the Howard Hughes Medical Institute, Stanford University Medical Center, Stanford, 94305, CA, USA

    Michael Povelones & Roel Nusse

Authors
  1. Michael Povelones
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Roel Nusse
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Povelones, M., Nusse, R. Wnt signalling sees spots. Nat Cell Biol 4, E249–E250 (2002). https://doi.org/10.1038/ncb1102-e249

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb1102-e249

  • Springer Nature Limited

This article is cited by

Search

Navigation