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HIF hits Wnt in the stem cell niche

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Distinct stem-cell populations are known to reside in hypoxic niches during development and postnatal life. Hypoxia-inducible transcription factors (HIFs) directly regulate the Wnt/β-catenin pathway to ensure the maintenance of both adult and embryonic stem cells.

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Figure 1: Hypoxia-mediated signalling through HIF1α functions to promote self-renewal of both adult and pluripotent stem-cell populations through the Wnt/β-catenin family of proteins.

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Authors and Affiliations

  1. Department of Medicine and Stem Cell Institute, Dan S. Kaufman is in the University of Minnesota, Minneapolis, MN 55455, USA. Kaufm020@umn.edu,

    Dan S. Kaufman

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  1. Dan S. Kaufman
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Kaufman, D. HIF hits Wnt in the stem cell niche. Nat Cell Biol 12, 926–927 (2010). https://doi.org/10.1038/ncb1010-926

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