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Tumorigenesis: Twist1 links EMT to self-renewal

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The epithelial–mesenchymal transition (EMT) occurs in pre-metastatic cancer cells and is also associated with the acquisition of stem-cell-like characteristics. A molecular link between EMT and stemness now emerges with the finding that Bmi1, a polycomb protein that promotes self-renewal of certain stem-cell populations, is a direct transcriptional target of the EMT inducer, Twist1.

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Figure 1: Molecular links are beginning to emerge between hypoxia, EMT and stemness.

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Authors and Affiliations

  1. Alberto Martin and Amparo Cano are in the Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid, IdiPAZ, Arzobispo Morcillo, 2, 28029 Madrid, Spain and the Instituto de Investigaciones Biomédicas “Alberto Sols” Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Arzobispo Morcillo, 2, 28029 Madrid, Spain.,

    Alberto Martin & Amparo Cano

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  1. Alberto Martin
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  2. Amparo Cano
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Correspondence to Amparo Cano.

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The authors declare no competing financial interests.

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Martin, A., Cano, A. Tumorigenesis: Twist1 links EMT to self-renewal. Nat Cell Biol 12, 924–925 (2010). https://doi.org/10.1038/ncb1010-924

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