Various microbes harness the actin polymerization machinery through their surface proteins to allow intracellular motility within host cells, but other virulence factors regulate dissemination. The cortical actin tension of polarized cells may represent a physical barrier that hinders the formation of microbial protrusions during cell-to-cell spreading.
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Romero, S., Van Nhieu, G. A bacterial virulence factor that dissipates tension. Nat Cell Biol 11, 1174–1175 (2009). https://doi.org/10.1038/ncb1009-1174
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DOI: https://doi.org/10.1038/ncb1009-1174
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