The evolutionarily conserved PAR3–PAR6–aPKC–Cdc42 complex has a well-established role in cell polarity. The exact job of PAR proteins in polarity is not known, but the finding that they affect endocytosis casts new light on their function.
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Wissler, F., Labouesse, M. PARtners for endocytosis. Nat Cell Biol 9, 1027–1029 (2007). https://doi.org/10.1038/ncb0907-1027
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DOI: https://doi.org/10.1038/ncb0907-1027
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