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Phagosomes, fatty acids and tuberculosis

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An acknowledged key to the success of Mycobacterium tuberculosis as a pathogen is its ability to prevent the fusion of a phagosome containing the internalized bacterium with the host cell's lysosomal system. Recent work examines the modulation of phagosome maturation by addition of exogenous fatty acids and discusses the implications that this could have for anti-tuberculosis therapy or prophylaxis.

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Figure 1: Phagosome maturation in cells infected with Mycobacterium.

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  1. Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, 14853, NY, USA

    David G. Russell

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  1. David G. Russell
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Russell, D. Phagosomes, fatty acids and tuberculosis. Nat Cell Biol 5, 776–778 (2003). https://doi.org/10.1038/ncb0903-776

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