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Homologue pairing: getting it right

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In Caernorhabditis elegans, homologue pairing is mediated by specialized regions near one end of each chromosome in conjunction with zinc finger (ZnF)-bearing proteins. Families of repeated sequences that are enriched within these regions have now been identified. By recruiting their cognate ZnF-bearing proteins, these regions promote pairing and synapsis.

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Figure 1: The tethering of pairing centres to the nuclear envelope facilitates meiotic pairing.

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Authors and Affiliations

  1. R. Scott Hawley and William D. Gilliland are at the Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA.,

    R. Scott Hawley & William D. Gilliland

  2. R. Scott Hawley is also in the Department of Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA. rsh@stowers.org,

    R. Scott Hawley

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  1. R. Scott Hawley
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  2. William D. Gilliland
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Hawley, R., Gilliland, W. Homologue pairing: getting it right. Nat Cell Biol 11, 917–918 (2009). https://doi.org/10.1038/ncb0809-917

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