Permeabilization of the mitochondria usually leads to caspase activation and apoptosis. In the absence of caspase activation, these same mitochondrial changes can also lead to cell death. A recent study suggests that when good mitochondria go bad, the activation of both glycolysis and autophagy may permit cellular survival.
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Song, S., Finkel, T. GAPDH and the search for alternative energy. Nat Cell Biol 9, 869–870 (2007). https://doi.org/10.1038/ncb0807-869
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DOI: https://doi.org/10.1038/ncb0807-869
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