Cdk2 is thought to regulate entry into S phase, whereas Cdk1 controls the initiation of mitosis. New evidence shows that Cdk1 is equally capable of promoting the G1/S transition in Cdk2−/− cells, raising the question as to whether Cdk1 constitutes the predominant cyclin-dependent kinase in mammalian cells, or only compensates for Cdk2 function when it is compromised.
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Bashir, T., Pagano, M. Cdk1: the dominant sibling of Cdk2. Nat Cell Biol 7, 779–781 (2005). https://doi.org/10.1038/ncb0805-779
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DOI: https://doi.org/10.1038/ncb0805-779
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