Cdc14 is a phosphatase that can antagonize CDK/cyclin cell-cycle functions. New insights from Caenorhabditis elegans show that CDC-14 is required to prevent cell-cycle entry during extended periods of developmentally regulated quiescence, and also clarify its role in creating the central mitotic spindle during anaphase.
References
Murray, A.W. Cell 116, 221–234 (2004).
Gray, C.H., Good, V.M., Tonks, N.K. & Barford, D. EMBO J. 22, 3524–3535 (2003).
Trautmann, S. & McCollum, D. Curr. Biol. 12, R733–R735 (2002).
Pereira, G. & Schiebel, E. Nature Cell Biol. 6, 473–475 (2004).
Gruneberg, U., Glotzer, M., Gartner, A. & Nigg, E.A. J. Cell Biol. 158, 901–914 (2002).
Saito, R.M. et al. Nature Cell Biol. 6, 777–783 (2004).
Lee, L.A. & Orr-Weaver, T.L. Annu. Rev. Genet. 37, 545–578 (2003).
Hong, Y., Roy, R. & Ambros, V. Development 125, 3585–3597 (1998).
Slingerland, J. & Pagano, M. J. Cell. Physiol. 183, 10–17 (2000).
Kaiser, B.K., Zimmerman, Z.A., Charbonneau, H. & Jackson, P.K. Mol. Biol. Cell 13, 2289–2300 (2002).
Wong, A.K. et al. Genomics 59, 248–251 (1999).
Mishima, M., Kaitna, S. & Glotzer, M. Dev. Cell 2, 41–54 (2002).
Mishima, M. et al. Nature DOI: 10.1038/nature02767 (2004).
Sijen, T. et al. Cell 107, 465–476 (2001).
Tijsterman, M. et al. Science 295, 694–697 (2002).
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Kipreos, E. Developmental quiescence: Cdc14 moonlighting in G1. Nat Cell Biol 6, 693–695 (2004). https://doi.org/10.1038/ncb0804-693
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DOI: https://doi.org/10.1038/ncb0804-693
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