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Delta traffic takes a sh-Arp turn

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In the Notch pathway, the transmembrane ligand Delta is internalized and then re-established on the surface of signal-sending cells to allow the productive binding and activation of the Notch receptor on neighbouring cells. Arp2/3-dependent actin polymerization directs Delta trafficking through this circuit.

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Figure 1: Drosophila sensory organ cells use an actin-rich structure to promote Notch pathway signalling.

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Authors and Affiliations

  1. Eyal D. Schejter is in the Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel. eyal.schejter@weizmann.ac.il,

    Eyal D. Schejter

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  1. Eyal D. Schejter
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Schejter, E. Delta traffic takes a sh-Arp turn. Nat Cell Biol 11, 791–793 (2009). https://doi.org/10.1038/ncb0709-791

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