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Centriole biogenesis: a tale of two pathways

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Two recent studies in Drosophila demonstrate that overexpression of proteins required for centriole duplication can not only induce centriole over-duplication in cells containing centrioles, but can also drive de novo centriole assembly in unfertilized eggs that initially lack centrioles. These studies offer a new perspective on the mechanisms that control centriole duplication.

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Figure 1: Effects of Sak/Plk4 overexpression in different cell types.
Figure 2: Mechanisms of centriole reduplication when Sak/Plk4 or Sas6 are overexpressed.

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Authors and Affiliations

  1. Jadranka Loncarek and Alexey Khodjakov are in the Division of Molecular Medicine, Wadsworth Center, Albany NY 12201–0509, USA. khodj@wadsworth.org,

    Jadranka Loncarek & Alexey Khodjakov

  2. Greenfield Sluder is in the Department of Cell Biology, University of Massachusetts Medical School, Worcester MA 01605, USA. Greenfield.Sluder@umassmed.edu,

    Greenfield Sluder

Authors
  1. Jadranka Loncarek
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  2. Greenfield Sluder
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  3. Alexey Khodjakov
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The authors declare no competing financial interests.

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Loncarek, J., Sluder, G. & Khodjakov, A. Centriole biogenesis: a tale of two pathways. Nat Cell Biol 9, 736–738 (2007). https://doi.org/10.1038/ncb0707-736

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