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Endosome sorting: GSE complex minds the Gap

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The general amino acids permease Gap1p provides yeast with sufficient amino acids to maintain protein synthesis. Gap1p is translocated to the plasma membrane when amino acids become limiting, a process that is mediated by a newly identified membrane complex called the GSE complex.

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Figure 1: Regulated trafficking of Gap1p under either nitrogen-rich or nitrogen-poor conditions.
Figure 2: Assembly of the GSE complex.

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  1. Cambridge Institute for Medical Research and Department of Clinical Biochemistry, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge, CB2 2XY, UK

    Matthew N. J. Seaman

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  1. Matthew N. J. Seaman
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Seaman, M. Endosome sorting: GSE complex minds the Gap. Nat Cell Biol 8, 648–649 (2006). https://doi.org/10.1038/ncb0706-648

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