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Unravelling mRNA export

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Precise spatial regulation of mRNA remodelling is crucial for proper gene expression. One way this is accomplished is through activation of the DEAD-box helicase Dbp5 at the cytoplasmic fibrils of the nuclear-pore complex, by the nucleoporin Gle1 and the soluble inositol polyphosphate InsP6.

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Figure 1: Dbp5 is selectively activated on the cytoplasmic fibrils of the NPC.

References

  1. Stutz, F. & Izaurralde, E. Trends Cell Biol. 13, 319–327 (2003).

    Article  CAS  Google Scholar 

  2. Weirich, C. et al. Nature Cell Biol. 8, 668–676 (2006).

    Article  CAS  Google Scholar 

  3. Alcázar-Román, A., Tran, E., Guo, S. & Wente, S. Nature Cell Biol. 8, 711–716 (2006).

    Article  Google Scholar 

  4. Cordin, O., Banroques, J., Tanner, N. & Linder P. Gene 367, 17–37 (2006).

    Article  CAS  Google Scholar 

  5. Snay-Hodge, C., Colot, H., Goldstein, A. & Cole, C. EMBO J. 17, 2663–2676 (1998).

    Article  CAS  Google Scholar 

  6. Tseng, S. et al. EMBO J. 17, 2651–2662 (1998).

    Article  CAS  Google Scholar 

  7. Zhao, J., Jin, S., Bjorkroth, B., Wieslader, L. & Daneholt, B. EMBO J. 21, 1177–1187 (2002).

    Article  CAS  Google Scholar 

  8. Hodge, C., Colot, H., Stafford, P. & Cole, C. EMBO J. 18, 5778–5788 (1999).

    Article  CAS  Google Scholar 

  9. York, J. D., Odom, A. R., Murphy, R., Ives, E. B. & Wente, S. R. Science 285, 96–100 (1999).

    Article  CAS  Google Scholar 

  10. Miller, A. et al. J. Biol. Chem. 279, 1022–1032 (2004).

    Google Scholar 

  11. Strahm, Y. et al. EMBO J. 18, 5761–5777 (1999).

    Article  CAS  Google Scholar 

  12. Weirich, C., Erzberger, J., Berger, J. & Weis, K. Mol. Cell 16, 749–760 (2004).

    Article  CAS  Google Scholar 

  13. Strasser, K., Bassler, J. & Hurt E. J. Cell Biol. 150 695–706 (2000).

    Article  CAS  Google Scholar 

  14. Lund, M. & Guthrie, C. Mol. Cell 20, 645–651 (2005).

    Article  CAS  Google Scholar 

  15. Fairman, M. et al. Science 304, 730–734 (2004).

    Article  CAS  Google Scholar 

  16. Jankowsky, E., Gross, C. H., Shuman, S. & Pyle, A. M. Nature 403, 447–451 (2000).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Departments of Biochemistry and Genetics, Dartmouth Medical School, Hanover, 03755, NH, USA

    Charles N. Cole

  2. Department of Biochemistry, Dartmouth Medical School, Hanover, 03755, NH, USA

    John J. Scarcelli

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  1. Charles N. Cole
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  2. John J. Scarcelli
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Cole, C., Scarcelli, J. Unravelling mRNA export. Nat Cell Biol 8, 645–647 (2006). https://doi.org/10.1038/ncb0706-645

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