New work reveals a key signal transduction pathway through which nitric oxide (NO) regulates apoptosis induced by disparate cellular stresses. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is S-nitrosylated by NO, which initiates an interaction with the E3 ligase Siah1, leading to nuclear translocation and ubiquitin-mediated degradation of nuclear target proteins.
References
Hibbs, J.B. Jr, Taintor, R.R., Vavrin, Z. & Rachlin, E.M. Biochem. Biophys. Res. Commun. 157, 87–94 (1988).
Dawson, V.L., Dawson, T.M., London, E.D., Bredt, D.S. & Snyder, S.H. Proc. Natl Acad. Sci. USA 88, 6368–6371 (1991).
Ischiropoulos, H., Zhu, L. & Beckman, J.S. Arch. Biochem. Biophys. 298, 446–451 (1992).
Lipton, S.A. et al. Nature 364, 626–632 (1993).
Stamler, J.S., Singel, D.J. & Loscalzo, J. Science 258, 1898–1902 (1992).
Mannick, J.B., Asano, K., Izumi, K., Kieff, E. & Stamler, J.S. Cell 79, 1137–1146 (1994).
Hess, D.T., Matsumoto, A., Kim, S.O., Marshall, H.E. & Stamler, J.S. Nature Rev. Mol. Cell Biol. 6, 150–166 (2005).
Eu, J.P., Liu, L., Zeng, M. & Stamler, J.S. Biochemistry 39, 1040–1047 (2000).
Liu, L. et al. Cell 116, 617–628 (2004).
Feechan, A. et al. Proc. Natl Acad. Sci. USA 102, 8054–8059 (2005).
Hara, M.R. et al. Nature Cell Biol. 7, 665–674 (2005).
Chuang, D.M., Hough, C. & Senatorov, V.V. Annu. Rev. Pharmacol. Toxicol. 45, 269–290 (2005).
Reed, J.C. & Ely, K.R. Nature Struct. Biol. 9, 8–10 (2002).
Molina y Vedia, L. et al. J. Biol. Chem. 267, 24929–24932 (1992).
Messmer, U.K. & Brune, B. Eur. J. Pharmacol. 302, 171–182 (1996).
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Benhar, M., Stamler, J. A central role for S-nitrosylation in apoptosis. Nat Cell Biol 7, 645–646 (2005). https://doi.org/10.1038/ncb0705-645
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DOI: https://doi.org/10.1038/ncb0705-645
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