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Wnt signalling escapes to cilia

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The primary cilium is proposed to restrain the level of canonical Wnt signalling, but it was unknown how the cilium achieves this. β-catenin, a component of the canonical Wnt signalling pathway, is now shown to be sequestered to the cilium by the Wnt signalling modulator Jouberin (Jbn) to restrain Wnt responses.

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Figure 1: Subcellular localization of Jbn and β-catenin in ciliated and non-ciliated cells, in the presence and absence of Wnt3A.

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Authors and Affiliations

  1. Rieko Ajima and Hiroshi Hamada are in the Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University and CREST, Japan Science and Technology Corporation (JST), 1-3 Yamada-oka, Suita, Osaka 565-0871, Japan,

    Rieko Ajima & Hiroshi Hamada

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  1. Rieko Ajima
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  2. Hiroshi Hamada
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Correspondence to Hiroshi Hamada.

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The authors declare no competing financial interests.

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Ajima, R., Hamada, H. Wnt signalling escapes to cilia. Nat Cell Biol 13, 636–637 (2011). https://doi.org/10.1038/ncb0611-636

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