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RNA surveillance by nuclear scanning?

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There are many quality-control mechanisms that ensure high fidelity of gene expression. One of these is the nonsense-mediated decay (NMD) pathway, which destroys aberrant mRNAs that contain premature termination codons generated as a result of biosynthetic errors or random and programmed gene mutations. Two complexes that initially bind to RNA in the nucleus have been suggested to be involved in NMD in the cytoplasm. Here we propose an alternative model that involves nuclear scanning, on the basis of recent evidence for nuclear translation.

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Figure 1: Model for nuclear nonsense-mediated decay (NMD).

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Acknowledgements

We thank T. Cooper, G. Cote, M. Goode, M. Moore, and N. Sonenberg, and members of the Wilkinson and Shyu laboratories for helpful comments. Special thanks go to L. Bankey for the artwork. Some of the work discussed here was supported by NIH grants (M.F.W. and A.-B.S.) and NSF grant (M.F.W.).

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Authors and Affiliations

  1. Department of Immunology, The University of Texas M.D. Anderson Cancer Center, Houston, 77030, Texas, USA

    Miles F. Wilkinson

  2. Department of Biochemistry and Molecular Biology, The University of Texas–Houston Medical School, Houston, 77030, Texas, USA

    Ann-Bin Shyu

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  1. Miles F. Wilkinson
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Wilkinson, M., Shyu, AB. RNA surveillance by nuclear scanning?. Nat Cell Biol 4, E144–E147 (2002). https://doi.org/10.1038/ncb0602-e144

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