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Transforming ER exit: protein secretion meets oncogenesis

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COPII-coated vesicles drive protein export from the endoplasmic reticulum (ER), although the regulation of this event, both spatially and kinetically, remains unclear. TFG is now defined as a factor that modulates recruitment of the coat and links ER sequestration of kinases to oncogenesis.

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Figure 1: TFG-1 modulates ER export and drives oncogenesis.

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Authors and Affiliations

  1. Silvere Pagant and Elizabeth Miller are in the Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue MC2456, New York, New York 10027, USA,

    Silvere Pagant & Elizabeth Miller

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  1. Silvere Pagant
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  2. Elizabeth Miller
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Correspondence to Elizabeth Miller.

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The authors declare no competing financial interests.

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Pagant, S., Miller, E. Transforming ER exit: protein secretion meets oncogenesis. Nat Cell Biol 13, 525–526 (2011). https://doi.org/10.1038/ncb0511-525

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