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iPS cells forgive but do not forget

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Induced pluripotent stem (iPS) cells offer the possibility to generate patient-specific cell types for use in regenerative medicine. However, a long-lasting question remains: are iPS and embryonic stem cells equivalent? iPS cells retain a transcriptional memory of their origin, which is now shown to endure with passages and to correlate with defects in the re-establishment of DNA methylation. Both selective pressure and genomic environment may account for these defects.

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Figure 1: Epigenetic events during reprogramming explain the molecular basis of iPS cell memory.

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Authors and Affiliations

  1. Maria J. Barrero and Juan Carlos Izpisua Belmonte are at The Center for Regenerative Medicine in Barcelona, Aiguader 88, E-08003 Barcelona, Spain,

    Maria J. Barrero & Juan Carlos Izpisua Belmonte

  2. Juan Carlos Izpisua Belmonte is also at The Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 North Torrey Pines Road, La Jolla, California 92037-1099, USA,

    Juan Carlos Izpisua Belmonte

Authors
  1. Maria J. Barrero
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  2. Juan Carlos Izpisua Belmonte
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Correspondence to Juan Carlos Izpisua Belmonte.

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The authors declare no competing financial interests.

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Barrero, M., Belmonte, J. iPS cells forgive but do not forget. Nat Cell Biol 13, 523–525 (2011). https://doi.org/10.1038/ncb0511-523

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