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SCAI blocks MAL-evolent effects on cancer cell invasion

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SCAI is a newly discovered protein that reduces cancer cell invasiveness. SCAI inhibits the MAL/SRF transcriptional activator complex that is downstream of Rho GTPase and actin, resulting in reduced expression of β1-integrins and loss of invasive potential.

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Figure 1: SCAI and the regulation of SRF transcription.

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Authors and Affiliations

  1. Rudy Juliano is in the Department of Pharmacology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina 27599-7365, USA. arjay@med.unc.edu,

    Rudy Juliano

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  1. Rudy Juliano
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Juliano, R. SCAI blocks MAL-evolent effects on cancer cell invasion. Nat Cell Biol 11, 540–542 (2009). https://doi.org/10.1038/ncb0509-540

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