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Breaking a temporal barrier: signalling crosstalk regulates the initiation of border cell migration

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Correct timing of developmental events is crucial for generating a normal organism. During oogenesis in Drosophila melanogaster, migration of border cells occurs in a defined temporal window and requires Jak/Stat and steroid hormone signalling. The initiation of border-cell migration is now shown to be timed by Jak/Stat-mediated downregulation of the BTB domain transcriptional regulator Abrupt, which acts as a negative regulator of steroid hormone signalling.

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Figure 1: Border cells develop from anterior follicle cells in response to a Jak/Stat activating signal from polar cells (curved arrows).

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Authors and Affiliations

  1. Dorothea Godt and Ulrich Tepass are in the Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, M5S 3G5, Canada. d.godt@utoronto.ca; u.tepass@utoronto.ca,

    Dorothea Godt & Ulrich Tepass

  2. u.tepass@utoronto.ca,

    Dorothea Godt & Ulrich Tepass

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  1. Dorothea Godt
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  2. Ulrich Tepass
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Godt, D., Tepass, U. Breaking a temporal barrier: signalling crosstalk regulates the initiation of border cell migration. Nat Cell Biol 11, 536–538 (2009). https://doi.org/10.1038/ncb0509-536

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