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Foot in mouth: do focal adhesions disassemble by endocytosis?

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How cells disassemble their focal adhesions is not well understood. Now, Ezratty et al. have shown that the GTPase dynamin acts after microtubule targeting of focal adhesions to trigger their disassembly. One intriguing possibility is that dynamin might drive disassembly through endocytosis.

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Figure 1: Dynamin is important for microtubule-targeted disassembly of a focal adhesion.

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  1. Department of Cell and Developmental Biology, and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 27599, NC, USA

    Keith Burridge

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  1. Keith Burridge
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Burridge, K. Foot in mouth: do focal adhesions disassemble by endocytosis?. Nat Cell Biol 7, 545–547 (2005). https://doi.org/10.1038/ncb0505-545

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