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Fatal liaisons of p53 with Bax and Bak

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p53 can induce apoptosis through its well defined role as a regulator of transcription, but also by a less well defined transcription-independent mechanism. Two recent studies demonstrate that p53 mediates mitochondrial permeabilization through direct physical interactions with the pro-apoptotic Bcl-2 family members, Bax and Bak.

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Figure 1: Interaction domains of p53 and Bcl-2 family proteins.
Figure 2: Pro-apoptotic p53–Bcl-2 family interactions at mitochondrial membranes.

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Authors and Affiliations

  1. the Apoptosis, Cancer & Immunity Laboratory associated with the National League against Cancer, CNRS-UMR8125, Institut Gustave Roussy, 39 rue Calmette Desmoulins, Villejuif, F-94805, France

    Jean-Luc Perfettini & Guido Kroemer

  2. Molecular Modeling and Design, Pharmacia, Viale Pasteur 10, Nerviano, 20014, MI, Italy

    Romano T. Kroemer

Authors
  1. Jean-Luc Perfettini
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  2. Romano T. Kroemer
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  3. Guido Kroemer
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Perfettini, JL., Kroemer, R. & Kroemer, G. Fatal liaisons of p53 with Bax and Bak. Nat Cell Biol 6, 386–388 (2004). https://doi.org/10.1038/ncb0504-386

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