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How Rab proteins link motors to membranes

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Small GTPases of the Rab family are essential for the control of membrane transport between intracellular compartments. Recent work has shown that on melanosome membranes, Rab27a initiates the formation of a receptor complex that allows the recruitment of the actin-based motor myosin Va. This study provides a molecular basis for several pathologies that result in pigmentation defects in both mouse and humans.

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Figure 1: Whole-mount electron microscopy of a melanoma cell line.
Figure 2: A model for Rab27a-dependent recruitment of myosin Va on melanosomes membranes.

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  1. the Institut Curie – Section de Recherche, 26 rue d'Ulm, Paris, 75005, France

    Bruno Goud

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  1. Bruno Goud
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Goud, B. How Rab proteins link motors to membranes. Nat Cell Biol 4, E77–E78 (2002). https://doi.org/10.1038/ncb0402-e77

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