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PTH battles TGF-β in bone

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Bone remodelling in vertebrates is coordinately regulated by the opposing effects of parathyroid hormone (PTH) and transforming growth factor-beta (TGF-β). PTH couples the processes of bone resorption and formation by enforcing simultaneous internalization of TGF-β type II receptor (TβRII) and PTH type 1 receptor (PTH1R), which attenuates both TGF-β and PTH signalling in vivo.

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Figure 1: PTH induces the internalization of TβRII–PTH1R complexes and attenuates PTH and TGF-β signalling.

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Authors and Affiliations

  1. Department of Oral Medicine, Azeddine Atfi is at NSERM UMRS 938, Hôpital St-Antoine, 184 Rue du Faubourg St-Antoine, 75571, Paris, France and Harvard School of Dental Medicine, Infection and Immunity, 188 Longwood Avenue, Boston, MA 02115, USA.,

    Azeddine Atfi

  2. Department of Medicine, Department of Oral Medicine, Roland Baron is at Harvard Medical School, Endocrine Unit, Massachusetts General Hospital and Harvard School of Dental Medicine, Infection and Immunity, 188 Longwood Avenue, Boston, MA 02115, USA.,

    Roland Baron

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  1. Azeddine Atfi
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  2. Roland Baron
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Correspondence to Azeddine Atfi.

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Atfi, A., Baron, R. PTH battles TGF-β in bone. Nat Cell Biol 12, 205–207 (2010). https://doi.org/10.1038/ncb0310-205

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