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A hypoxic twist in metastasis

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Hypoxia is a critical factor during tumour progression, regulating the expression of multiple factors implicated in tumour growth, epithelial to mesenchymal transition (EMT) and invasive cell behaviour. We now learn that the EMT inducer Twist operates under the control of hypoxia signalling in the tumour microenvironment.

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Figure 1: Intratumoural hypoxia modulates metastasis through upregulation of TWIST and other EMT regulators.

References

  1. Harris, A. L. Nature Rev. Cancer 2, 38–47 (2002).

    Article  CAS  Google Scholar 

  2. Brahimi-Horn, M. C., Chiche, J. & Pouyssegur, J. J. Mol. Med. 85, 1301–1307 (2007).

    Article  PubMed  Google Scholar 

  3. Yang, M. H. et al. Nature Cell Biol. 10, 295–305 (2008).

    Article  CAS  PubMed  Google Scholar 

  4. Semenza, G. L. Nature Rev. Cancer 3, 721–732 (2003).

    Article  CAS  Google Scholar 

  5. Thiery, J. P. Nature Rev. Cancer. 2, 442–454 (2002).

    Article  CAS  Google Scholar 

  6. Higgins, D. F. et al. J. Clin. Invest. 117, 3810–3820 (2007).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Peinado, H., Olmeda, D. & Cano, A. Nature Rev. Cancer 7, 415–428 (2007).

    Article  CAS  Google Scholar 

  8. Evans, A. J. et al. Mol. Cell Biol. 27, 157–169 (2007).

    Article  CAS  PubMed  Google Scholar 

  9. Krishnamachary, B. et al. Cancer Res. 66, 2725–2731 (2006).

    Article  CAS  PubMed  Google Scholar 

  10. Erler, J. T. et al. Nature 440, 1222–1226 (2006).

    Article  CAS  PubMed  Google Scholar 

  11. Yang, J. et al. Cell 117, 927–939 (2004).

    Article  CAS  Google Scholar 

  12. Alexander, N. R. et al. Cancer Res. 66, 3365–3369 (2006).

    Article  CAS  PubMed  Google Scholar 

  13. Ma, L., Teruya-Feldstein, J. & Weinberg, R. A. Nature 449, 682–688 (2007).

    Article  CAS  PubMed  Google Scholar 

  14. Scheel, C., Onder, T., Karnoub, A. & Weinberg, R. A. Cancer Res. 67, 11476–11479 (2007).

    Article  CAS  PubMed  Google Scholar 

  15. Thiery, J. P. & Sleeman, J. P. Nature Rev. Mol. Cell Biol. 7, 131–142 (2006).

    Article  CAS  Google Scholar 

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Peinado, H., Cano, A. A hypoxic twist in metastasis. Nat Cell Biol 10, 253–254 (2008). https://doi.org/10.1038/ncb0308-253

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