The multi-functionality of the adenomatous polyposis coli (APC) tumour suppressor gene keeps surprising cancer molecular biologists. Signal transduction, cytoskeletal organization, chromosomal segregation and cell adhesion are just some of the putative cellular functions previously assigned to this gene and thought to be related to its tumour-suppressing activity. New data on yet another tumour-related function of APC, namely the coordinated regulation of cell adhesion and motility, adds to its host of cellular activities.
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Fodde, R. The multiple functions of tumour suppressors: it's all in APC. Nat Cell Biol 5, 190–192 (2003). https://doi.org/10.1038/ncb0303-190
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DOI: https://doi.org/10.1038/ncb0303-190
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