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Multitasking at mitotic exit

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Separase is a conserved protease that activates the metaphase-to-anaphase transition by cleaving the link between sister chromatids. Furthermore, in Saccharomyces cerevisiae, separase is also involved in promoting mitotic exit through regulating Cdc14 release. A new study now suggests that the mitotic exit function of separase is independent from its protease activity.

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Figure 1: The multiple roles of separase.

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Authors and Affiliations

  1. Laboratory of Molecular and Cellular Biology, National Institute of Diabetes and Digestive Kidney Disease, The National Institutes of Health, 8 Center Drive, Bethesda, 20892, MD, USA

    Karen E. Ross & Orna Cohen-Fix

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  1. Karen E. Ross
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  2. Orna Cohen-Fix
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Ross, K., Cohen-Fix, O. Multitasking at mitotic exit. Nat Cell Biol 5, 188–189 (2003). https://doi.org/10.1038/ncb0303-188

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