Mutations in either of two polycystin genes can cause kidney failure, but controversy remains regarding the cellular localization and function of the protein products. Polycystin-2 may be a calcium release channel located within the endoplasmic reticulum (ER), and yet may be physically linked to polycystin-1 in the surface membrane.
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Cahalan, M. The ins and outs of polycystin-2 as a calcium release channel. Nat Cell Biol 4, E56–E57 (2002). https://doi.org/10.1038/ncb0302-e56
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DOI: https://doi.org/10.1038/ncb0302-e56
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