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Mitochondria get a Parkin' ticket

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Recent studies have revealed a prominent role of mitochondrial dysfunction in the development of one of the most common neurodegenerative disorders, Parkinson's disease. The ubiquitin ligase Parkin and the protein kinase PINK1, whose mutations are associated with Parkinson's disease, function in a pathway that links ubiquitylation with selective autophagy of damaged mitochondria.

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Figure 1: Model of PINK1/Parkin-mediated mitophagy.

References

  1. Shults, C. W. Proc. Natl Acad. Sci. USA 103, 1661–1668 (2006).

    Article  CAS  Google Scholar 

  2. Kitada, T. et al. Nature 392, 605–608 (1998).

    Article  CAS  Google Scholar 

  3. Poole, A. C. et al. Proc. Natl Acad. Sci. USA 105, 1638–1643 (2008).

    Article  CAS  Google Scholar 

  4. Geisler, S. et al. Nature Cell Biol. 12, 119–131 (2010).

    Article  CAS  Google Scholar 

  5. Park, J., Kim Y. & Chung, J. Dis. Model Mech. 2, 336–340 (2009).

    Article  CAS  Google Scholar 

  6. Narendra, D., Tanaka, A., Suen D. F., & Youle R. J. J. Cell Biol. 183, 795–803 (2008).

    Article  CAS  Google Scholar 

  7. Vives-Bauza, C. et al. Proc. Natl Acad. Sci. USA 107, 378–383 (2010).

    Article  CAS  Google Scholar 

  8. Kirkin, V., McEwan, D. G., Novak & Dikic, I. Mol. Cell 34, 259–269 (2009).

    Article  CAS  Google Scholar 

  9. Okamato, K., Kondo-Okamato, N. & Ohsumi, Y. Dev. Cell 17, 87–97 (2009).

    Article  Google Scholar 

  10. Kanki, T. et al. Dev. Cell 17, 98–109 (2009).

    Article  CAS  Google Scholar 

  11. Novak, I. et al. EMBO Rep. 11, 45–51 (2010).

    Article  CAS  Google Scholar 

  12. Sutovsky, P. et al. Nature 402, 371–372 (1999).

    Article  CAS  Google Scholar 

  13. Ikeda, F. & Dikic, I. EMBO Rep. 9, 536–542 (2008).

    Article  CAS  Google Scholar 

  14. Dikic, I., Wakatsuki, S. & Walters K. J. Nature Rev. Mol. Cell Biol. 10, 659–671 (2009).

    Article  CAS  Google Scholar 

  15. Li, W. et al. PloS One 3, e1487 (2008).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Philipp Wild and Ivan Dikic are at the Goethe University Medical School, Institute of Biochemistry II and Frankfurt Institute for Molecular Life Sciences, Theodor-Stern-Kai 7, Frankfurt a.M., D-60590, Germany.,

    Philipp Wild & Ivan Dikic

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  1. Philipp Wild
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  2. Ivan Dikic
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Correspondence to Ivan Dikic.

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Wild, P., Dikic, I. Mitochondria get a Parkin' ticket. Nat Cell Biol 12, 104–106 (2010). https://doi.org/10.1038/ncb0210-104

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