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Facing up to Mena: Tes(ting) times for EVH1 domains

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Ena/VASP family members have a common binding interface on their EVH1 domains for FPPPP motifs in partner proteins. The finding that Tes, a protein lacking FPPPP motifs, competes specifically for the FPPPP ligand site on Mena, provides new insights into the differential regulation of Ena/VASP proteins.

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Figure 1: Competition for EVH1 domains of vertebrate Ena/VASP proteins between LIM domain- containing proteins and proteins containing FP4 motifs.
Figure 2: Modulation of Mena activity by Tes.

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Authors and Affiliations

  1. J. Victor Small is at the Austrian Academy of Sciences, IMBA - Institute of Molecular Biotechnology, Dr. Bohr-Gasse 3, 1030 Vienna, Vienna, A-1030, Austria. vic.small@imba.oeaw.ac.at,

    J. Victor Small

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Small, J. Facing up to Mena: Tes(ting) times for EVH1 domains. Nat Cell Biol 10, 118–120 (2008). https://doi.org/10.1038/ncb0208-118

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