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FoxM1 dances with mitosis

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The mammalian Forkhead Box M1 (FoxM1) protein, known for its function as a transcriptional regulator of G1/S progression, is also crucial for the G2/M transition. Some of its target genes are cyclin B, Cdc25B phosphatase, Aurora B kinase and Polo-like kinase. Furthermore, identification of the nuclear protein CENP-F as a transcriptional target of FoxM1 reveals how it can also regulate the spindle assembly checkpoint, thereby ensuring proper chromosome stability and segregation during mitosis.

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Figure 1: FoxM1 transcription factor regulates transcription of cell-cycle genes essential for G2/M progression, chromosomal segregation and cytokinesis.

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  1. Department of Biochemistry and Molecular Genetics (M/C 669), University of Illinois at Chicago, College of Medicine, 900 S. Ashland Ave, MBRB Rm. 2220, Chicago, 60607-7170, IL, USA

    Robert H. Costa

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  1. Robert H. Costa
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Costa, R. FoxM1 dances with mitosis. Nat Cell Biol 7, 108–110 (2005). https://doi.org/10.1038/ncb0205-108

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