Skip to main content
SpringerLink
Log in

Membrane repair redux: redox of MG53

  • News & Views
  • Published:

From Nature Cell Biology

View current issue Submit your manuscript

Most cells can rapidly repair extensive tears in their plasma membrane, a response dependent on extracellular calcium. Entry of extracellular oxidants through a membrane disruption oxidizes and thus activates a newly discovered membrane repair protein, MG53, in skeletal muscle cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: A model for membrane repair.

References

  1. Clarke, M. S., Khakee, R. & McNeil, P. L. J. Cell Sci. 106, 121–133 (1993).

    CAS  PubMed  Google Scholar 

  2. Bansal, D. et al. Nature 423, 168–172 (2003).

    Article  CAS  Google Scholar 

  3. Steinhardt, R. A., Bi, G. & Alderton, J. M. Science 263, 390–393 (1994).

    Article  CAS  Google Scholar 

  4. Verkhratsky, A. Subcell. Biochem. 45, 465–480 (2007).

    Article  CAS  Google Scholar 

  5. Heilbrunn, L. V. Proc. Am. Philos. Soc. LXIX, 295–301 (1930).

    Google Scholar 

  6. Cai, C. et al. Nature Cell Biol. 11, 56–64 (2008).

    Article  Google Scholar 

  7. McNeil, P. L. & Kirchhausen, T. Nature Rev. Mol. Cell Biol. 6, 499–505 (2005).

    Article  CAS  Google Scholar 

  8. McNeil, A. K., Rescher, U., Gerke, V. & McNeil, P. L. J. Biol. Chem. 281, 35202–35207 (2006).

    Article  CAS  Google Scholar 

  9. Bansal, D. & Campbell, K. P. Trends Cell Biol. 14, 206–213 (2004).

    Article  CAS  Google Scholar 

  10. Bi, G. Q. et al. J. Cell Biol. 138, 999–1008 (1997).

    Article  CAS  Google Scholar 

  11. Mellgren, R. L., Zhang, W., Miyake, K. & McNeil, P. L. J. Biol. Chem. 282, 2567–2575 (2007).

    Article  CAS  Google Scholar 

  12. Clarke, M. S., Caldwell, R. W., Chiao, H., Miyake, K. & McNeil, P. L. Circ. Res. 76, 927–934 (1995).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cellular Biology and Anatomy, Paul McNeil is at the Medical College of Georgia, 1120 15th Street, CB 2816, Augusta, GA 30912-2000, USA pmcneil@mail.mcg.edu,

    Paul McNeil

Authors
  1. Paul McNeil
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

McNeil, P. Membrane repair redux: redox of MG53. Nat Cell Biol 11, 7–9 (2009). https://doi.org/10.1038/ncb0109-7

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb0109-7

  • Springer Nature Limited

This article is cited by

Search

Navigation