Bone morphogenetic proteins (BMPs) shape vertebrate limbs and define digits by inducing programmed cell death in interdigital tissues. Recent findings show that Drosophila legs are also sculpted by programmed cell death. In this case, rather than the absolute activity of BMP, it is the sharp discontinuity of BMP signalling that is required for forming the leg joint.
References
Zou, H. & Niswander, L. Science 272, 738–741 (1996).
Yu, S.Y. et al. Development 129, 3269–3278 (2002).
Manjón, C., Sánchez-Herrero, E. & Suzanne, M. Nature Cell Biol. 9, 57–63 (2007).
Lecuit, T. & Cohen, S.M. Nature 388, 139–145 (1997).
Rauskolb, C. Development 128, 4511–4521 (2001).
Rauskolb, C. & Irvine, K.D. Dev. Biol. 210, 339–350 (1999).
de Celis, J.F., Tyler, D.M., de Celis, J. & Bray, S. Development 125, 4617–4626 (1998).
Bishop, S.A., Klein, T., Martinez Arias, A. & Couso, J.P. Development 126, 2993–3003 (1999).
Chai, J. et al. Nature 406, 855–862 (2000).
Adachi-Yamada, T., Fujimura-Kamada, K., Nishida, Y. & Matsumoto, K. Nature 400, 166–169 (1999).
Lohmann, I., McGinnis, N., Bodmer, M. & McGinnis, W. Cell 110, 457–466 (2002).
Niwa, N. et al. Development 127, 4373–4381 (2000).
Jockusch, E.L. Nulsen, C., Newfeld, S.J. & Nagy, L.M. Development 127, 1617–1626 (2000).
Shen, J. & Dahmann, C. Science 307, 1789–1790 (2005).
Gibson, M.C. & Perrimon, N. Science 307, 1785–1789 (2005).
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Milán, M. Sculpting a fly leg: BMP boundaries and cell death. Nat Cell Biol 9, 17–18 (2007). https://doi.org/10.1038/ncb0107-17
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DOI: https://doi.org/10.1038/ncb0107-17
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