Skip to main content
SpringerLink
Log in

Leading-edge research: PtdIns(3,4,5)P3 and directed migration

  • News & Views
  • Published:

From Nature Cell Biology

View current issue Submit your manuscript

New studies reveal the dynamic accumulation of phosphatidylinositol (3,4,5) trisphosphate (PtdIns(3,4,5)P3) at the leading edge of primary neutrophils during chemotaxis. They also demonstrate that SHIP1, rather than phosphatase and tensin homologue (PTEN), is responsible for the degradation and localization of this lipid in neutrophils and shed light on the role of PtdIns(3,4,5)P3 in directional sensing.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: The effect of PtdIns(3, 4, 5)P3 levels on chemotaxis.
Figure 2: Schematic representation of a model for directional sensing.

References

  1. Weiner, O. Curr. Opin. Cell Biol. 14, 196–202 (2002).

    Article  CAS  Google Scholar 

  2. Franca-Koh, J., Kamimura, Y. & Deveotes, P.N. Curr. Opin. Genet. Dev. 16, 333–338 (2006).

    Article  CAS  Google Scholar 

  3. Meili, R. et al. EMBO J. 18, 2092–2105 (1999).

    Article  CAS  Google Scholar 

  4. Servant, G. et al. Science 287, 1037–1040 (2000).

    Article  CAS  Google Scholar 

  5. Parent, C.A. & Devreotes, P.N. Science 284, 765–770 (1999).

    Article  CAS  Google Scholar 

  6. Funamoto, S., Meili, R., Lee, S., Parry, L. & Firtel, R.A. Cell 109, 611–623 (2002).

    Article  CAS  Google Scholar 

  7. Iijima, M. & Devreotes, P.N. Cell 109, 599–610 (2002).

    Article  CAS  Google Scholar 

  8. Ward, S.G. Trends Immunol. 27, 80–87 (2006).

    Article  CAS  Google Scholar 

  9. Nishio, M. et al. Nature Cell Biol. 9, 36–44 (2007).

    Article  CAS  Google Scholar 

  10. Ferguson, G.J. et al. Nature Cell Biol. 9, 86–91 (2007).

    Article  CAS  Google Scholar 

  11. Helgason, C.D. et al. Genes Dev. 12, 1610–1620 (1998).

    Article  CAS  Google Scholar 

  12. Liu, Q. et al. Genes Dev. 13, 786–791 (1999).

    Article  CAS  Google Scholar 

  13. Van Keymeulen, A. et al. J. Cell Biol. 174, 437–445 (2006).

    Article  CAS  Google Scholar 

  14. Chen, L. et al. Mol. Biol. Cell. 14, 5028–5037 (2003).

    Article  CAS  Google Scholar 

  15. Hannigan, M. et al. Proc. Natl Acad. Sci. USA 99, 3603–3608 (2002).

    Article  CAS  Google Scholar 

  16. Loovers, H.M. et al. Mol. Biol. Cell 17, 1503–1513 (2006).

    Article  CAS  Google Scholar 

  17. Sasaki, A.T., Chun, C., Lee, S., Takeda, K. & Firtel, R.A. J. Cell Biol. 167, 505–518 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cell Biology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, 114 WBSB, Baltimore, 21205, MD, USA

    Jonathan Franca-Koh, Yoichiro Kamimura & Peter N. Devreotes

Authors
  1. Jonathan Franca-Koh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yoichiro Kamimura
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Peter N. Devreotes
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Franca-Koh, J., Kamimura, Y. & Devreotes, P. Leading-edge research: PtdIns(3,4,5)P3 and directed migration. Nat Cell Biol 9, 15–17 (2007). https://doi.org/10.1038/ncb0107-15

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb0107-15

  • Springer Nature Limited

This article is cited by

Search

Navigation