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A phosphatase for cofilin to be HAD

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Regulating actin dynamics through cofilin dephosphorylation is the role of a newly identified phosphatase, chronophin, a member of the haloacid dehalogenase (HAD) superfamily. Chronophin, the second cofilin phosphatase to be identified, has high phosphoprotein specificity towards cofilin, but curiously it was also discovered independently as a pyridoxal phosphate (vitamin B6) phosphatase.

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Figure 1: The activity of ADF/cofilin is regulated by a balance of phosphorylation and dephosphorylation.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, 80523, CO, USA

    O'Neil Wiggan, Barbara W. Bernstein & James R. Bamburg

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  1. O'Neil Wiggan
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  2. Barbara W. Bernstein
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  3. James R. Bamburg
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Wiggan, O., Bernstein, B. & Bamburg, J. A phosphatase for cofilin to be HAD. Nat Cell Biol 7, 8–9 (2005). https://doi.org/10.1038/ncb0105-8

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