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MicroRNAs fine-tune oncolytic viruses

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Targeting by tissue-specific microRNAs enhances the efficacy and safety of tumor-killing viruses.

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Figure 1: Control of transgene expression by tissue-specific miRNAs.

Katie Ris-Vicari

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Authors and Affiliations

  1. John C. Bell is in the Ottawa Health Research Institute, Ottawa, Ontario K1G 0K8, Canada jbell@ohri.ca,

    John C Bell

  2. David Kirn is at Jennerex Inc., One Market St., Spear Tower, Suite 2260, San Francisco, California 94105, USA. dkirn@jennerex.com,

    David Kirn

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  1. John C Bell
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  2. David Kirn
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Competing interests

J.C.B. is scientific officer of Jennerex, Inc., a company developing oncolytic virus therapeutics.

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Bell, J., Kirn, D. MicroRNAs fine-tune oncolytic viruses. Nat Biotechnol 26, 1346–1348 (2008). https://doi.org/10.1038/nbt1208-1346

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