Where combinatorial chemistry and genomics have stalled, could an exploration of untapped sources usher in a second golden age of antibiotic discovery? Cormac Sheridan investigates.
References
He, H. et al. J. Am. Chem. Soc. 124, 9729–9736 (2002).
Wang, J. et al. Nature 441, 358–361 (2006).
Thouzeau, C. et al. J. Biol. Chem. 278, 51053–51058 (2003).
Mackintosh, J.A. et al. Can. J. Microbiol. 41, 136–144 (1995).
Handelsman, J. et al. Chem. Biol. 5, R245–R249 (1998).
Brady, S.F. & Clardy, J. J. Nat. Prod. 67, 1283–1286 (2004).
Gillespie, D.E. et al. Appl. Environ. Microbiol. 68, 4301–4306 (2002).
Mincer, T.J. et al. Appl. Environ. Microbiol. 68, 5005–5011 (2002).
Kaeberlein, T. et al. Science 296, 1127–1129 (2002).
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Sheridan, C. Antibiotics au naturel. Nat Biotechnol 24, 1494–1496 (2006). https://doi.org/10.1038/nbt1206-1494
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DOI: https://doi.org/10.1038/nbt1206-1494
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