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Killers come to the rescue

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T cells genetically modified to express a peptide–MHC complex, normally involved in the induction of autoimmunity, can kill pathogenic T cells and inhibit autoimmune disease.

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Figure 1: T cells transgenically expressing MHC–MBP89–101 peptide complexes can inhibit early and late stages of EAE in mice.

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Authors and Affiliations

  1. assistant professor, Department of Medicine Karolinska Institutet, Center for Molecular Medicine, Stockholm, S-171 76, Sweden

    Marie Wahren-Herlenius

  2. associate professor, Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, 02115, MA

    Vijay K. Kuchroo

Authors
  1. Marie Wahren-Herlenius
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  2. Vijay K. Kuchroo
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Wahren-Herlenius, M., Kuchroo, V. Killers come to the rescue. Nat Biotechnol 20, 1205–1206 (2002). https://doi.org/10.1038/nbt1202-1205

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