Pharmacogenomics will help explain why drugs work better in some patients than in others. These tools should be used as early in the drug development process as possible.
References
Pharmaceutical Researchers and Manufacturers of America.
Poirer,J. et al. 1995. Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer's disease. Proc. Natl. Acad. Sci. USA 92: 12260–12264.
Farlow, M.R. et al. 1996. Apolipoprotein E genotype and gender influence response to tacrine therapy. Ann. NY Acad. Sci. 802: 101–110.
Richard, F. et al. 1997. APOE genotyping and response to drug treatment in Alzheimer's disease. Lancet 349: 539.
Department of Health and Human Services. 1997. Guidance for Industry: Drug Metabolism/Drug Interaction Studies in the Drug Development Process: Studies in Vitro. FDA, Rockville, MD.
Rights and permissions
About this article
Cite this article
Marshall, A. Getting the right drug into the right patient. Nat Biotechnol 15, 1249–1252 (1997). https://doi.org/10.1038/nbt1197-1249
Issue Date:
DOI: https://doi.org/10.1038/nbt1197-1249
- Springer Nature America, Inc.
This article is cited by
-
Why pharmacogenomics? Why now?
Nature Biotechnology (1998)