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Making drug addicts out of yeast

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Yeast has been engineered so that the binding of small-molecule ligands to a target protein can be simply detected by changes in growth.

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Figure 1: Yeast dhr1 mutant strains carrying a murine DHFR chimeric protein can be used as a biosensor for drug discovery.

© Bob Crimi

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Authors and Affiliations

  1. Susana Vidan is a postdoctoral fellow and Michael Snyder is professor and chairman, Department of Molecular, Cellular and Developmental Biology, Yale University, P.O. Box 208103, New Haven, 06520-8103, CT

    Susana Vidan & Michael Snyder

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  1. Susana Vidan
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  2. Michael Snyder
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Vidan, S., Snyder, M. Making drug addicts out of yeast. Nat Biotechnol 19, 1022–1023 (2001). https://doi.org/10.1038/nbt1101-1022

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