Epigenomics provides the context for understanding the function of genome sequence, analogous to the functional anatomy of the human body provided by Vesalius a half-millennium ago. Much of the seemingly inconclusive genetic data related to common diseases could therefore become meaningful in an epigenomic context.
References
Vesalius, A. De humani corporis fabrica libri septem (J. Oporini, Basel, Switzerland, 1543).
McKusick, V.A. J. Am. Med. Assoc. 286, 2289–2295 (2001).
Proudfoot, N.J., Shander, M.H., Manley, J.L., Gefter, M.L. & Maniatis, T. Science 209, 1329–1336 (1980).
Crossley, M. & Orkin, S.H. Curr. Opin. Genet. Dev. 3, 232–237 (1993).
Viville, S. & Surani, M.A. Bioessays 17, 835–838 (1995).
Boggs, B.A. et al. Nat. Genet. 30, 73–76 (2002).
Bernstein, B.E. et al. Cell 120, 169–181 (2005).
van Steensel, B. & Dekker, J. Nat. Biotechnol. 28, 1089–1095 (2010).
Cai, S., Lee, C.C. & Kohwi-Shigematsu, T. Nat. Genet. 38, 1278–1288 (2006).
Sandhu, K.S. et al. Genes Dev. 23, 2598–2603 (2009).
Kapranov, P., Willingham, A.T. & Gingeras, T.R. Nat. Rev. Genet. 8, 413–423 (2007).
Yu, W. et al. Nature 451, 202–206 (2008).
MacFarlane, L.A., Gu, Y., Casson, A.G. & Murphy, P.R. Mol. Endocrinol. 24, 800–812 (2010).
Gupta, R.A. et al. Nature 464, 1071–1076 (2010).
Wen, B., Wu, H., Shinkai, Y., Irizarry, R.A. & Feinberg, A.P. Nat. Genet. 41, 246–250 (2009).
Hawkins, R.D. et al. Cell Stem Cell 6, 479–491 (2010).
Peric-Hupkes, D. et al. Mol. Cell 38, 603–613 (2010).
Smith, S.T. et al. Dev. Biol. 328, 518–528 (2009).
Schwartz, Y.B. et al. PLoS Genet. 6, e1000805 (2010).
Lieberman-Aiden, E. et al. Science 326, 289–293 (2009).
Feinberg, A.P. & Vogelstein, B. Nature 301, 89–92 (1983).
Frigola, J. et al. Nat. Genet. 38, 540–549 (2006).
Irizarry, R.A. et al. Nat. Genet. 41, 178–186 (2009).
Fraga, M.F. et al. Nat. Genet. 37, 391–400 (2005).
Lister, R. et al. Nature 462, 315–322 (2009).
Doi, A. et al. Nat. Genet. 41, 1350–1353 (2009).
Saterlee, J., Schubeler, D. & Ng, H. Nat. Biotechnol. 28, 1039–1044 (2010).
Portela, A. & Esteller, M. Nat. Biotechnol. 28, 1057–1068 (2010).
Manolio, T.A. et al. Nature 461, 747–753 (2009).
Goldstein, D.B. N. Engl. J. Med. 360, 1696–1698 (2009).
Wade, N. A decade later, genetic map yields few new cures. New York Times (12 June 2010).
Bjornsson, H.T., Fallin, M.D. & Feinberg, A.P. Trends Genet. 20, 350–358 (2004).
Petronis, A., Paterson, A.D. & Kennedy, J.L. Schizophr. Bull. 25, 639–655 (1999).
Jiang, Y.H., Bressler, J. & Beaudet, A.L. Annu. Rev. Genomics Hum. Genet. 5, 479–510 (2004).
Gondor, A. & Ohlsson, R. Nature 461, 212–217 (2009).
Kerkel, K. et al. Nat. Genet. 40, 904–908 (2008).
Gibbs, J.R. et al. PLoS Genet. 6, e1000952 (2010).
Feinberg, A.P. & Irizarry, R.A. Proc. Natl. Acad. Sci. USA 107 Suppl 1, 1757–1764 (2010).
Feinberg, A.P. et al. Sci. Transl. Med. 2, 49ra67 (2010).
Deng, J. et al. Nat. Biotechnol. 27, 353–360 (2009).
Bernstein, B.E. et al. Nat. Biotechnol. 28, 1045–1048 (2010).
Barton, N.H., Briggs, D.E.G., Eisen, J.A., Goldstein, D.B. & Patel, N.H. Evolution (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, USA, 2007).
Acknowledgements
I thank E. Pujadas, K. Reddy and R. Ohlsson for comments on the manuscript. This work was supported by US National Institutes of Health grant 5R37CA054358.
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Feinberg, A. Epigenomics reveals a functional genome anatomy and a new approach to common disease. Nat Biotechnol 28, 1049–1052 (2010). https://doi.org/10.1038/nbt1010-1049
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DOI: https://doi.org/10.1038/nbt1010-1049
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