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New β-cells from old acini

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Pancreatic acinar cells have been reprogrammed in vivo into insulin-expressing cells by adenoviral delivery of three transcription factors.

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Figure 1: An outline of the model used by Melton and colleagues1.

Katie Ris-Vicari

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Authors and Affiliations

  1. Michael S. German is at the University of California, San Francisco Diabetes Center, 513 Parnassus Avenue, HSW 1090, Box 0534, San Francisco, California 94143, USA. mgerman@diabetes.ucsf.edu ,

    Michael S German

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  1. Michael S German
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Competing interests

M.S.G. is a Novocell, Inc., Scientific Advisory Board Member and stockholder. He is the inventor on six issued US patents pertaining to the delivery of genes to exocrine glands, one issued US patent for human Neurogenin3, and two issued US patents for the use of Neurogenin3 for the production of insulin-producing cells. All of these patents are held by the University of California.

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German, M. New β-cells from old acini. Nat Biotechnol 26, 1092–1093 (2008). https://doi.org/10.1038/nbt1008-1092

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