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Enhancing immunity to HIV through APOBEC

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A small molecule that interferes with HIV Vif promotes the antiviral activity of the human protein APOBEC3G.

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Figure 1: Targeting the A3G-Vif axis.

References

  1. Sheehy, A.M., Gaddis, N.C., Choi, J.D. & Malim, M.H. Nature 418, 646–650 (2002).

    Article  CAS  PubMed  Google Scholar 

  2. Haché, G., Shindo, K., Albin, J.S. & Harris, R.S. Curr. Biol. 18, 819–824 (2008).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Nathans, R. . Nat. Biotechnol. 26, 1187–1192 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Yu, X. et al. Science 302, 1056–1060 (2003).

    Article  CAS  PubMed  Google Scholar 

  5. Harris, R.S. et al. Cell 113, 803–809 (2003).

    Article  CAS  PubMed  Google Scholar 

  6. Mangeat, B. et al. Nature 424, 99–103 (2003).

    Article  CAS  PubMed  Google Scholar 

  7. Zhang, H. et al. Nature 424, 94–98 (2003).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Xiao, Z. et al. FASEB J. 21, 217–222 (2007).

    Article  CAS  PubMed  Google Scholar 

  9. Mehle, A. et al. J. Virol. 81, 13235–13241 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Loeb, L.A. et al. Proc. Natl. Acad. Sci. USA 96, 1492–1497 (1999).

    Article  CAS  PubMed  Google Scholar 

  11. Harris, R.S., Petersen-Mahrt, S.K. & Neuberger, M.S. Mol. Cell 10, 1247–1253 (2002).

    Article  CAS  PubMed  Google Scholar 

  12. Schumacher, A.J., Nissley, D.V. & Harris, R.S. Proc. Natl. Acad. Sci. USA 102, 9854–9859 (2005).

    Article  CAS  PubMed  Google Scholar 

  13. Mulder, L.C., Harari, A. & Simon, V. Proc. Natl. Acad. Sci. USA 105, 5501–5506 (2008).

    Article  CAS  PubMed  Google Scholar 

  14. Simon, V. et al. PLoS Pathog. 1, e6 (2005).

    Article  PubMed  PubMed Central  Google Scholar 

  15. Rose, K.M., Marin, M., Kozak, S.L. & Kabat, D. J. Biol. Chem. 279, 41744–41749 (2004).

    Article  CAS  PubMed  Google Scholar 

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Harris, R. Enhancing immunity to HIV through APOBEC. Nat Biotechnol 26, 1089–1090 (2008). https://doi.org/10.1038/nbt1008-1089

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