Chromosomal integration of rAAV vectors may induce hepatocellular carcinoma in neonatally treated mice.
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Katie Ris-Vicari
References
Donsante, A. et al. Science 317, 477 (2007).
Donsante, A. et al. Gene Ther. 8, 1343–1346 (2001).
http://www4.od.nih.gov/oba/rac/Transcript3-7-011.pdf (2001).
Bell, P. et al. Mol. Ther. 12, 299–306 (2005).
Nakai, H. et al. J. Virol. 75, 6969–6976 (2001).
Nakai, H. et al. Nat. Genet. 34, 297–302 (2003).
Nakai, H. et al. J. Virol. 79, 3606–3614 (2005).
Miller, D.G., Petek, L.M. & Russell, D.W. Nat. Genet. 36, 767–773 (2004).
Inagaki, K. et al. J. Virol., published online 8 August 2007 (doi:10.1128/JVI.00963-07).
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Kay, M. AAV vectors and tumorigenicity. Nat Biotechnol 25, 1111–1113 (2007). https://doi.org/10.1038/nbt1007-1111
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DOI: https://doi.org/10.1038/nbt1007-1111
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