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Antibodies in the breakdown lane

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An engineered IgG induces degradation of endogenous IgG, providing a potential therapeutic approach to autoimmune disease.

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Figure 1: FcRn normally protects IgG from degradation by diverting endogenous IgG from lysosomes.

Bob Crimi

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Authors and Affiliations

  1. Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, 02115, Massachusetts, USA

    Richard S Blumberg

  2. Children's Hospital Medical Center and Harvard Medical School, 300 Longwood Avenue, Boston, 02115, USA, Massachusetts

    Wayne I Lencer

Authors
  1. Richard S Blumberg
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  2. Wayne I Lencer
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Blumberg, R., Lencer, W. Antibodies in the breakdown lane. Nat Biotechnol 23, 1232–1234 (2005). https://doi.org/10.1038/nbt1005-1232

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