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Antibody-drug conjugates ace the tolerability test

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Near-uniform, low-level conjugation of cytotoxins to antitumor antibodies increases their tolerability without compromising efficacy.

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Figure 1: Schematic representation of site-specific conjugation of potent cytotoxic drugs (red stars) to a conventional IgG monoclonal antibody (mAb) or a THIOMAB—a mAb carrying the A114C mutation in the heavy chain.

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  1. Nitin K. Damle was in the Oncology Discovery Research Division of Wyeth Research, Pearl River, New York 10965, USA. ndamle56@gmail.com,

    Nitin K Damle

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Damle, N. Antibody-drug conjugates ace the tolerability test. Nat Biotechnol 26, 884–885 (2008). https://doi.org/10.1038/nbt0808-884

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