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Looking Death In The Eye: Apoptosis And Cancer Research

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Abstract

Is cancer really caused by cells refusing to commit suicide on cue?

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References

  1. Barres, B., Hart, I., Coles, H., Burne, J., Voyvodic, J., Richardson, W. and Raff, M. 1992. Cell death and control of cell survival in the oligodendrocyte lineage. cell 70: 31–46.

    Article  CAS  Google Scholar 

  2. Ellis, H. and Horvitz, H. 1986. Genetic control of programmed cell death in the nematode C. elegans. cell 44: 817–829.

    Article  CAS  Google Scholar 

  3. Hengartner, M., Ellis, R. and Horvitz, H. 1992. Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature 356: 494–499.

    Article  CAS  Google Scholar 

  4. Askew, D., Ashmun, R., Simmons, B. and Cleveland, J. 1991. Constitutive c-myci expression in an Il-3-dependent myeloid cell line suppressed cell cycle arrest and accelerates apoptosis. Oncogens 6: 1915–1922.

    CAS  Google Scholar 

  5. Shi, Y., Bissonnette, R., Glynn, J., Guilbert, L., Cotter, T. and Green, D. 1992. Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas. Science 257: 212–214.

    Article  CAS  Google Scholar 

  6. Bissonnette, R., Echeverri, F., Mahboubi, A. and Green, D. 1992. Apoptotic cell death induced by c-myc is inhibited by bcl-2. Nature 359: 552–554.

    Article  CAS  Google Scholar 

  7. Smeyne, R., Vendrell, M., Hayward, M., Baker, S., Miso, G., Schilling, K., Robertson, L., Curran, T. and Morgan, J. 1993. Continuous c-fos expression precedes programmed cell death in vivo. Nature 363: 168–169.

    Article  Google Scholar 

  8. Lowe, S., Schmitt, E., Smith, S., Osborne, B. and Jacks, T. 1993. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362: 847–849.

    Article  CAS  Google Scholar 

  9. Clarke, A., Purdie, C., Harrison, D., Morris, R., Bird, C., Hooper, M. and Wyllie, A. 1993. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 362: 849–852.

    Article  CAS  Google Scholar 

  10. Miyashita, T. and Reed, J. 1993. Bcl-2 oncoprotein blocks chemo therapy-induced apoptosis in a human leukemia cell line. Blood 81: 151–157.

    CAS  PubMed  Google Scholar 

  11. Reed, J., Stein, C., Subasinghe, C., Haldar, S., Croce, C., Yum, S. and Cohen, J. 1990.Antisense mediated inhibition of BCL2 protooncogene expression and leukemic cell growth and survival: Comparisons of phosphodiester and phosphorothioate oligodeoxynucleotides. Cancer Research 50: 6565–6570.

    CAS  PubMed  Google Scholar 

  12. Curran, T. and Morgan, J. 1985. Superinduction by fos by nerve growth factor in the presence of peripherally active benzodiaz epines. Science 229: 1265–1268.

    Article  CAS  Google Scholar 

  13. Tian, Q., Streuli, M., Saito, H., Schlossman, S. and Anderson, P. 1991. A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells. cell 67: 629–639.

    Article  CAS  Google Scholar 

  14. Tomei, D., Shapiro, J. and Cope, F. 1993. Apoptosis in C3H/101/2 mouse embryonic cells: Evidence for internucleosomal DNA modification in the absence of double-strand cleavage. Proc. Natl. Acad. Sci. U.S.A. 90: 853–857.

    Article  CAS  Google Scholar 

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Edgington, S. Looking Death In The Eye: Apoptosis And Cancer Research. Nat Biotechnol 11, 787–792 (1993). https://doi.org/10.1038/nbt0793-787

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  • DOI: https://doi.org/10.1038/nbt0793-787

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